Let me draw an analogy for you. Suppose a world where free will existed. What do you expect to see?
I’m not sure if this is actually true, but many philosophers would implicitly BELIEVE that only one out of the theories of personal identity makes sense due to flaws in the others- that one clearly represents what humans are. To answer your original question, if only one theory were true I would expect the others to have some sort of flaw or philosophical incoherence which makes them not make sense.
Clearly, however, some have been ‘screwed over’ less than others at the very least- there are large numbers of people for whom the dislikable alleles aren’t even noticed.