There are new synthetic nootropics for memory enhancement, like isrib. Anybody familiar? I don’t see it discusses here
Structural insights into ISRIB, a memory-enhancing inhibitor of the integrated stress response
The integrated stress response (ISR) regulates protein synthesis under conditions of stress. Phosphorylation of translation initiation factor eIF2 by stress-sensing kinases converts eIF2 from substrate to competitive inhibitor of its dedicated nucleotide exchange factor, eIF2B, arresting translation. A drug-like molecule called integrated stress response inhibitor (ISRIB) reverses the effects of eIF2 phosphorylation and restores translation by targeting eIF2B. When administered to mice, ISRIB enhances cognition and limits cognitive decline due to brain injury. To determine ISRIB’s mechanism of action, we solved an atomic structure of ISRIB bound to the human eIF2B decamer. We found that ISRIB acts as a molecular staple, pinning together tetrameric subcomplexes of eIF2B along the assembly path to a fully active, decameric enzyme. In this Structural Snapshot, we discuss ISRIB’s mechanism, its ability to rescue disease mutations in eIF2B and conservation of the enzyme and ISRIB-binding pocket.
If you haven’t been aware, reddit’s /r/nootropics is censoring the new synthetic nootropics that many people found useful. for example one of the newest nootropics with interesting science behind it is isrib. there are whole communities behind it because of the censorship on the main /r/nootropics subreddit https://reddit.com/r/isrib, etc. here is a youtube link explaining science behind it: