belkarx0 AT outlook.com
belkarx
Karma: 218
when you compare caffeine to paraxanthine, are you comparing caffeine pills or coffee? cuz coffee has a bunch of other things in there that could be confounding. its also really hard to isolate eg gut motility, receptor saturation, circadian dynamics in PK, so prolly good to normalize those if comparing.
curious about whether the crash is worse, if anyone caffeine crash prone tries, would be cool to get an update
if you are willing to part with half your eggs per cycle, you can get it done for free (w something like cofertility, tho supposedly they’re sorta predatory)
I think maybe it’s worth waiting to recommend to 19yos until we can do ex vivo maturation (no hormone shots), which will be available sooner than the stem cell eggs, just bc messing w hormones when young is bad (tho if someone’s risk tolerance allows for longterm use of estrogen containing birth control like many women accept then egg freezing is prob ok?)
NIH Cancer Myths Myths
yes. but they were subtle.
Oh I totally forgot to mention control theory, add that.
ctrl theory: brian douglas on yt
3d sketching: just draw things from models you’ll get better QUICK
optics, signal processing: I learned from youtube, choice MIT lectures, implementing sims, etc but there are probably good textbooks
abstract algebra: An Infinitely Large Napkin (I stan this book so hard)
This may be a me thing but I draw stuff out when I ideate (esp w hardware) and more dimensions → better physical models → better, faster iteration speed mental models
the enneagram fears and motivations. Good compression of a lot of people.
IMPROV
better 3d sketching
architecture (think burglar‘s guide to the city), urbex
optics (lotsa good metaphors)
signal processing
abstract algebra
side comment that I’ve been reminded of: epigenetics *exist(s?)*. I wonder if that could somehow be a more naturally integrate-able approach
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251063/
I like the premise. I’m glad this is getting researched. But:
Lots of things in the space are understudied and the startup-vibe approach of “we’ll figure this all out on the way because previous papers don’t exist” seems way less likely to work with bio than tech because of the length of iteration cycles. But props if it does?
Black swan effects of polygenic edits
cellular stress if on a large scale?
might be an exception where pleiotropy does actually matter, which would suck. the table in another comment showing correlations between illnesses is pretty convincing however it’s possible there are effects that aren’t quantified there (doesn’t present as diagnosable disease)
???? not sufficiently enmeshed in the bio space but this entire post gives off the vibe of “most of the components are bleeding edge and there aren’t many papers, esp not large scale/long term ones” and I imagine that’ll cause more issues than you expect and streeeetch timescales
given black box bio and difficulty of studying the brain, it’s really hard to tell what’s being left out in studies that measure only change in intelligence/what other things are being affected
We have gotten nowhere near as much as we could out of behavioral interventions (on long timescales) and nootropics, and both of those seem like better areas to put research time into. I don’t actually think a research project of this scale will be faster (for AI safety research etc) than either of those.
counterpoint: this will just make it easier/lower ‘energy’ to apply interventions and is hence worthwhile?? but it’s still so risky that I maintain the above approaches are more worthwhile in the short term
Do the people who contract things out because their time is worth $n/hr or whatever actually keep track of how many “extra” hours they work on top of their basic expenses such that they know how much work they can practically expense out? Or is this a thing that people just say and don’t stop to actually think through. Very much has the vibes of a family with 300k+ takehome or whatever living paycheck to paycheck cuz they’re too good for certain things
There is no such thing as the present, and you are experiencing everything that can possibly be experienced
Deja vu is actually the only time you’re not repeating things infinitely
no creative, original thought exists. everything has been thought, and you’ve just forgotten. you know everything, you just don’t know that you know everything
An actually appropriate replacement for what literature should be trying to develop is debate
I would be interested in dialoguing about:
- why the “imagine AI as a psychopath” analogy for possible doom is or isn’t appropriate (I brought this up a couple months ago and someone on LW told me Eliezer argued it was bad, but I couldn’t find the source and am curious about reasons)- how to maintain meaning in life if it seems that everything you value doing is replaceable by AI (and mere pleasure doesn’t feel sustainable)
Doesn’t 80k hours do this?
Research on the effectivity of hypnosis as an analgesic and in general
How does cyronic neuropreservation consider the peripheral and enteric nervous systems? why do they assume CNS is enough?
I had been communicating with someone who had had great success and very fine control with modification, so that was a clear “this is possible” (they were much more careful though!), and I was also reflecting a lot on how people don’t explicitly take advantage of their self modifying properties enough (it is amazing that we can just … will thoughts and goals into existence and delude ourselves like what?? and the % of people that meditate is low??! the heck?).
I think my success was mostly due to just being in a frame of mind that made me very receptive to change, I think if you’re fighting it because you, at some level, believe your current equilibrium is better than what you’re aiming for (probably the case, tbh) or unaware to what extent change is possible you’d have much weaker results. Also, I had very little explicit, continuous certainty in my goals and habits, rendering them quite susceptible to change.
Bad sleep schedule is another good example of something that gets romanticised when it shouldn’t.
There is a strong analogy to be made between human psychopaths and misaligned AI
note that there are factors that can make your absorption of meds slower or more/less effective and getting a vibe for this before taking larger doses of meds bc its “not working” (yet?) is probably a good idea
also everyone should get WGS for their CYP and UGT and stuff and adjust/choose meds accordingly
and +1 on the tylenol+ibuprofen combo, godly for refractory/chronic pain (esp in the context of tolerance to either)