Armand_Cognetta

• Armand_Cognetta 18 Dec 2023 5:50 UTC

  2 points

  0

  on: The likely first longevity drug is based on sketchy sci­ence. This is bad for sci­ence and bad for longevity.

  Loyal gave their IGF-1 inhibitor to healthy laboratory dogs (and possibly diabetic dogs, although it’s hard to tell). Lo and behold, it lowered IGF-1. It probably also reduced insulin. They then looked at healthy pet dogs, and found that big dogs had higher levels of IGF-1, which is one of the reasons they’re big. Small dogs had lower levels of IGF-1. Small dogs, as we all know, live longer than big dogs. Therefore, Loyal said, our IGF-1 inhibitor will extend the life of dogs.

  Needless to say, this is bad science. Really bad science.

  FYI there is a long history of the study of IGF in aging. EG see here or here.

• Armand_Cognetta 2 Jul 2023 4:08 UTC

  2 points

  2

  on: Alpha

  I don’t have anything substantive to say, but I just wanted to comment that I thought this was a wonderful read.