Interesting. I wasn’t aware of many of the things you cited.
I think that most adult (or really post-zygotic) intelligence amplification approaches, including those you outlined, are unlikely to give more than maybe 15 IQ. As my median AGI timeline is ~8y, I think genomics will be too slow as well, but it’s still worth trying.
For the metabolism thing, I really wouldn’t expect more efficient lactate shuttles to improve intelligence if baseline lactate production didn’t change. What’s the point of better lactate shuttling, if not to provide more lactate?
I’m more optimistic about edits to myelin; there may not have been particularly strong fitness pressures on signal jitter until very recently, and time-coding is important for neural representations. Also, highly insulative myelin would reduce axonal crosstalk, though I’m unsure by how much.
Interesting. I wasn’t aware of many of the things you cited.
I think that most adult (or really post-zygotic) intelligence amplification approaches, including those you outlined, are unlikely to give more than maybe 15 IQ. As my median AGI timeline is ~8y, I think genomics will be too slow as well, but it’s still worth trying.
For the metabolism thing, I really wouldn’t expect more efficient lactate shuttles to improve intelligence if baseline lactate production didn’t change. What’s the point of better lactate shuttling, if not to provide more lactate?
I’m more optimistic about edits to myelin; there may not have been particularly strong fitness pressures on signal jitter until very recently, and time-coding is important for neural representations. Also, highly insulative myelin would reduce axonal crosstalk, though I’m unsure by how much.