If “the wavefunction is real, but it is a function over potential configurations, only one of which is real.” then you have the real configuration interacting with potential configurations. I don’t see how you can say something isn’t real (if only one of them is real then the others aren’t) is interacting with something that is. If that “potential” part of the wave function can interact with the other parts of the wave function, then it’s clearly real in every sense that the word “real” means anything at all.
If “the wavefunction is real, but it is a function over potential configurations, only one of which is real.” then you have the real configuration interacting with potential configurations. I don’t see how you can say something isn’t real (if only one of them is real then the others aren’t) is interacting with something that is. If that “potential” part of the wave function can interact with the other parts of the wave function, then it’s clearly real in every sense that the word “real” means anything at all.