Interesting! Speaking as a person not remotely knowledgeable about transcription factors, I’d be interested if you could elaborate on that first sentence, if you get a chance. :)
Basically if FOXP2 is mutated and functionally impaired, then it’s reasonable to assume all the cells that express FOXP2 will be affected. FOXP2 is expressed in the whole striatum (and other parts of the brain too) not just regions involved in speech. See: https://academic.oup.com/brain/article/126/11/2455/403806
Speaking as a biologist knowledgeable about transcription factors, I would also favor hypothesis 2.
I would also add that the idea of there being a “language gene” is quite outdated. Complex traits such as language are highly polygenic.
Interesting! Speaking as a person not remotely knowledgeable about transcription factors, I’d be interested if you could elaborate on that first sentence, if you get a chance. :)
Basically if FOXP2 is mutated and functionally impaired, then it’s reasonable to assume all the cells that express FOXP2 will be affected. FOXP2 is expressed in the whole striatum (and other parts of the brain too) not just regions involved in speech. See: https://academic.oup.com/brain/article/126/11/2455/403806