For dosing, I think we based the dose on the Deadwyler et. al. study in monkeys as well as user experiences.
Unfortunate that a 10-20x dose in humans seems to have small effects? I would have expected them to use a C-terminal -NH2 modification on their Orexin-A to prevent degradation, but it doesn’t look like it (but maybe they did and I missed it). If that’s the case, might reduce the effective dose gap between ours and theirs somewhat.
I’m excited to see our results at a higher dose, though part of me is frustrated by how difficult peptides are to work with. But hopefully Takeda or someone else will perfect small-molecule orexin agonists!
Thanks for this background, it’s super helpful!
For dosing, I think we based the dose on the Deadwyler et. al. study in monkeys as well as user experiences.
Unfortunate that a 10-20x dose in humans seems to have small effects? I would have expected them to use a C-terminal -NH2 modification on their Orexin-A to prevent degradation, but it doesn’t look like it (but maybe they did and I missed it). If that’s the case, might reduce the effective dose gap between ours and theirs somewhat.
I’m excited to see our results at a higher dose, though part of me is frustrated by how difficult peptides are to work with. But hopefully Takeda or someone else will perfect small-molecule orexin agonists!