>Usually it will copy into non-coding DNA, and then be suppressed, so there’s no noticeable effect. But over time, the transposon count increases, the suppressor count doesn’t increase, and eventually the transposons get out of control.
Wouldn’t it expand the size of the genome and potentially affect the distance between promoters/enhancers and target genes, causing a loss in a cell’s ability to appropriately regulate translation in response to perturbation?
I know some people (like genesis lung) who actively take lysine or antiretrovirals to suppress transposon activity—antiretrovirals may be aassociated with longevity./
Wouldn’t it expand the size of the genome and potentially affect the distance between promoters/enhancers and target genes, causing a loss in a cell’s ability to appropriately regulate translation in response to perturbation?
To some extent, though presumably the vast majority of copies will be into non-functional sequence, and copies into functional sequence will often result in a defective cell which is quickly removed. The expansion of the genome size shouldn’t be significant until the count is already way out of control; a transposon is tiny compared to the whole genome.
>Usually it will copy into non-coding DNA, and then be suppressed, so there’s no noticeable effect. But over time, the transposon count increases, the suppressor count doesn’t increase, and eventually the transposons get out of control.
Wouldn’t it expand the size of the genome and potentially affect the distance between promoters/enhancers and target genes, causing a loss in a cell’s ability to appropriately regulate translation in response to perturbation?
I know some people (like genesis lung) who actively take lysine or antiretrovirals to suppress transposon activity—antiretrovirals may be aassociated with longevity./
To some extent, though presumably the vast majority of copies will be into non-functional sequence, and copies into functional sequence will often result in a defective cell which is quickly removed. The expansion of the genome size shouldn’t be significant until the count is already way out of control; a transposon is tiny compared to the whole genome.