At the fourth attempt, my doctor managed to get the local lab to test TSH,T3 and T4 simultaneously. He had to ring them up and ask them in person, apparently. It turns out that I’ve currently got TSH~2.5, and FT4,FT3 low-in-range. Given that that looks like central hypothyroidism, and that’s under the influence of 1 grain/day of desiccated thyroid, we’ve decided we that we have no clue, and I’m carrying on messing around with random thyroid drugs aiming for relief of symptoms (which are all gone, but I keep having to up the dose to keep it so).
Basically Christ knows. If I’m not medically unique, there’s something very funny going on.
That’s what I was expecting, but 2.5 isn’t suppressed, it’s actually quite high compared to the average for healthy people, (or at least normal, depending on what you think normal is). And roughly the same as it was at the start of all this. And both the free hormones look low. You’d think adding a fair bit of thyroid to a healthy system would have bumped up the free hormones and maybe lowered TSH to somewhere like the hyperthyroid range.
What’s really weird is that I’ve tripled the dose of NDT since the last time I had blood drawn, and my TSH has gone up slightly in response. I thought I’d be seriously suppressing my own system by now.
It’s possible that I’ve just developed a primary gland failure, but that’s weird because there was no sign of it when I first showed severe symptoms.
Ok so your TSH is normal and your T3/T4 are low in the normal range because you’ve replaced them with some T1/T2. Every value is in the normal range. Problem?
It makes no sense at all to call it pituitary failure (central hypothyroidism) - that would imply low TSH. You could argue that it’s successfully medicated peripheral hypothyroidism if anything, though that’s a stretch.
At the fourth attempt, my doctor managed to get the local lab to test TSH,T3 and T4 simultaneously. He had to ring them up and ask them in person, apparently. It turns out that I’ve currently got TSH~2.5, and FT4,FT3 low-in-range. Given that that looks like central hypothyroidism, and that’s under the influence of 1 grain/day of desiccated thyroid, we’ve decided we that we have no clue, and I’m carrying on messing around with random thyroid drugs aiming for relief of symptoms (which are all gone, but I keep having to up the dose to keep it so).
Basically Christ knows. If I’m not medically unique, there’s something very funny going on.
Aren’t you just taking thyroid hormones analogues (not T3/T4) that are—as expected—suppressing the pituitary production of TSH?
That’s what I was expecting, but 2.5 isn’t suppressed, it’s actually quite high compared to the average for healthy people, (or at least normal, depending on what you think normal is). And roughly the same as it was at the start of all this. And both the free hormones look low. You’d think adding a fair bit of thyroid to a healthy system would have bumped up the free hormones and maybe lowered TSH to somewhere like the hyperthyroid range.
What’s really weird is that I’ve tripled the dose of NDT since the last time I had blood drawn, and my TSH has gone up slightly in response. I thought I’d be seriously suppressing my own system by now.
It’s possible that I’ve just developed a primary gland failure, but that’s weird because there was no sign of it when I first showed severe symptoms.
Ok so your TSH is normal and your T3/T4 are low in the normal range because you’ve replaced them with some T1/T2. Every value is in the normal range. Problem?
It makes no sense at all to call it pituitary failure (central hypothyroidism) - that would imply low TSH. You could argue that it’s successfully medicated peripheral hypothyroidism if anything, though that’s a stretch.