(See also kman’s comment.) Besides the technical difficulties with trying the experiments, it’s quite unclear how much effect you can have on an adult brain via editing. There are important ~irreversible changes from childhood to adult brains, such as lock-in of many synapses through PNNs, pruning of long-range connections, and commitment to which axons to myelinate. (Adult brains are more capable than child brains in many respects, but this tends to be based on “crystallized intelligence”; to go bigger, I’m guessing you want more child-like learning capabilities; though that’s just speculation.) Even for IQ genes that are expressed in adult brains, it’s plausible their effects on IQ are mainly or linearly coming from childhood effects.
My uninformed impression of E11 is that it’s very cool, but also is not the bottleneck to WBE or similar. The connectome isn’t the issue, the issue is actually getting the neural behavior that does the important work. (Cf. maybe this: https://www.youtube.com/watch?v=FHQfmJEpRmU ) IDK about Eon, but my impression from listening to others is that their announcement was super misleading / nothingburger. Separately, I think WBE in particular is much more risky than most other HIA approaches.
What is Michael Levin doing with his bioelectricity?
I highly doubt this is relevant.
In general there is the issue that it’s hard to test what you’re interested in; and you’re not constrained to the natural manifold (as with reprogenetics), so there’s little guarantee that e.g. increasing reaction time would generalize to increased philosophical insight or whatnot.
All that said, of course we should be investing much more into this.
(See also kman’s comment.) Besides the technical difficulties with trying the experiments, it’s quite unclear how much effect you can have on an adult brain via editing. There are important ~irreversible changes from childhood to adult brains, such as lock-in of many synapses through PNNs, pruning of long-range connections, and commitment to which axons to myelinate. (Adult brains are more capable than child brains in many respects, but this tends to be based on “crystallized intelligence”; to go bigger, I’m guessing you want more child-like learning capabilities; though that’s just speculation.) Even for IQ genes that are expressed in adult brains, it’s plausible their effects on IQ are mainly or linearly coming from childhood effects.
My uninformed impression of E11 is that it’s very cool, but also is not the bottleneck to WBE or similar. The connectome isn’t the issue, the issue is actually getting the neural behavior that does the important work. (Cf. maybe this: https://www.youtube.com/watch?v=FHQfmJEpRmU ) IDK about Eon, but my impression from listening to others is that their announcement was super misleading / nothingburger. Separately, I think WBE in particular is much more risky than most other HIA approaches.
I don’t believe the claim about simulating something close enough to neurons; see the previous point. Re/ BCIs, see also: https://www.lesswrong.com/posts/pFzctpJBat95SrCyC/ai-2040-plan-a?commentId=ff9c8PHtuFKfwE6Yj
I highly doubt this is relevant.
In general there is the issue that it’s hard to test what you’re interested in; and you’re not constrained to the natural manifold (as with reprogenetics), so there’s little guarantee that e.g. increasing reaction time would generalize to increased philosophical insight or whatnot.
All that said, of course we should be investing much more into this.