I don’t know of any good studies on this, but from reading lots of anecdotes on reddit, yeah, some trans people do have quite atypical reactions to starting HRT. Unfortunately these can sometimes be negative changes to energy and mood, though ‘no change’ or ‘positive change’ is more common. Among those who have negative changes, some stay on HRT anyway because the psychological benefits from the physical changes (less dysphoria) are more significant than the negative energy/mood impacts.
I don’t know of any good studies on this, but from reading lots of anecdotes on reddit, yeah, some trans people do have quite atypical reactions to starting HRT. Unfortunately these can sometimes be negative changes to energy and mood, though ‘no change’ or ‘positive change’ is more common. Among those who have negative changes, some stay on HRT anyway because the psychological benefits from the physical changes (less dysphoria) are more significant than the negative energy/mood impacts.