Another thing that may be a potential blocker is that lesswrong has been identified with the whole SIAI/singularity/transhumanism cluster.
I’d say a prime example of something else (i.e. aside from the friendly AI problem) that lesswrong is well suited for is making more real progress in the development of cryonics.
I’d say a prime example of something else (i.e. aside from the friendly AI problem) that lesswrong is well suited for is making more real progress in the development of cryonics.