so the maximum “downside” would be the sum of the differences between that reference populations lives and those without the variant for all variants you edit (plus any effects from off-targets)
I don’t think that’s true? It has to assume the variants don’t interact with each other. Your reference population would only have 0.01% people with (the rarest) 2 variants at once, 0.0001% with 3 variants, and so on.
I don’t think that’s true? It has to assume the variants don’t interact with each other. Your reference population would only have 0.01% people with (the rarest) 2 variants at once, 0.0001% with 3 variants, and so on.