Idea (not sure how good) for the controlled substances:
In addition to the list of banned molecules, also keep a list of most common alterations. Like, if adding a fluorine atom is a typical hack, add “anything on this list plus one fluorine atom, unless the result is on the whitelist”.
Idea (not sure how good) for the controlled substances:
In addition to the list of banned molecules, also keep a list of most common alterations. Like, if adding a fluorine atom is a typical hack, add “anything on this list plus one fluorine atom, unless the result is on the whitelist”.
Still whack-a-mole, but with a larger hammer.