Nice. Yeah seems hard to estimate, not least because the major sources of damage probably enter the germline continuously over time. E.g. the proliferation step itself (cell division introduces very very roughly 1 de novo mutation), and steps of oocyte epigenetic reprogramming and maturation, are ongoing during development, adding a trickle of variation in oocyte quality. So the variation that you’re selecting on is inherently changing over time. (I guess qualitatively, this would increase the relative importance of the final steps of selection. IDK if this matters quantitatively.)
Anyway, I don’t have the bandwidth to investigate more, but I’d encourage you to write a little report for LW if you’re interested (just be sure to keep marking where your facts are coming from AI summaries as opposed to being checked from papers). As evidenced by this OP, a lot of people are interested!
I spent perhaps a bit too much of the days bandwidth allocation on this conversation myself, but I’ll see if I can find the time during the week to summarize it in case anyone’s interested.
Also I would have loved to attend your conference, and its actually during a quiet part of my holiday, but unfortunately I think the 15 hour transatlantic flight might be a little bit too steep of a threshold 😅
Nice. Yeah seems hard to estimate, not least because the major sources of damage probably enter the germline continuously over time. E.g. the proliferation step itself (cell division introduces very very roughly 1 de novo mutation), and steps of oocyte epigenetic reprogramming and maturation, are ongoing during development, adding a trickle of variation in oocyte quality. So the variation that you’re selecting on is inherently changing over time. (I guess qualitatively, this would increase the relative importance of the final steps of selection. IDK if this matters quantitatively.)
Anyway, I don’t have the bandwidth to investigate more, but I’d encourage you to write a little report for LW if you’re interested (just be sure to keep marking where your facts are coming from AI summaries as opposed to being checked from papers). As evidenced by this OP, a lot of people are interested!
Also, you may be interested in attending this conference I’m organizing, featuring lots of experts on related areas: https://www.reproductivefrontiers.org/
I spent perhaps a bit too much of the days bandwidth allocation on this conversation myself, but I’ll see if I can find the time during the week to summarize it in case anyone’s interested.
Also I would have loved to attend your conference, and its actually during a quiet part of my holiday, but unfortunately I think the 15 hour transatlantic flight might be a little bit too steep of a threshold 😅