A second related question is whether there’s a possibility of building a college course—or college-like course, perhaps a MOOC—specifically revolving around mastery of the content in LessWrong (perhaps starting with the Sequences).
Would such a college course be possible to design in principle? How would such a college course compare with core requirements for undergraduates today?
There has been at least one comment and at least one post on it before, so it appears there is active interest.
Yes. See also Course recommendations for Friendliness researchers, Help Reform A Philosophy Curriculum and Train Philosophers with Pearl and Kahneman, not Plato and Kant.