FWIW, I think that in some sort of hypothetical involving a bunch more resources (something like $200 million -- $1 billion, maybe), you could plausibly technically get to strong reprogenetic HIA within 5 or 10 years. This would go through IVG plus either iterated CRISPR, iterated recombinant selection, and/or chromosome selection. (Then you’d have to wait for the kids to grow up, and as you say, uptake would be slow at first and would see regulatory obstacles.)
I suspect you’d need to spend those resources in some jurisdiction advanced enough to be a good place to do biomedical research yet small enough that it would be willing to take a hands-off attitude with an investment of that size. Places like Singapore or Costa Rica come to mind.
FWIW, I think that in some sort of hypothetical involving a bunch more resources (something like $200 million -- $1 billion, maybe), you could plausibly technically get to strong reprogenetic HIA within 5 or 10 years. This would go through IVG plus either iterated CRISPR, iterated recombinant selection, and/or chromosome selection. (Then you’d have to wait for the kids to grow up, and as you say, uptake would be slow at first and would see regulatory obstacles.)
I suspect you’d need to spend those resources in some jurisdiction advanced enough to be a good place to do biomedical research yet small enough that it would be willing to take a hands-off attitude with an investment of that size. Places like Singapore or Costa Rica come to mind.