Thanks. One of the first places I’d look would be hormones, which IIUC don’t count as small molecules? Though maybe natural hormones have already been tried? But I’d wonder about more obscure or risky ones, e.g. ones normally only active in children.
Some would count as small (e.g. cortisol, testosterone). But there’s also protein hormones. Honestly dunno but I expect we’d understand the effects of those kinds of molecules fairly well, if only because almost for all of them there is a condition where you have too little or too much of it providing a natural experiment.
Hm. TBC, the broader category would be “molecule that would activate master regulation of one or more gene regulatory networks related to brain function”, e.g. a hormone but maybe also some other things.
Thanks. One of the first places I’d look would be hormones, which IIUC don’t count as small molecules? Though maybe natural hormones have already been tried? But I’d wonder about more obscure or risky ones, e.g. ones normally only active in children.
Some would count as small (e.g. cortisol, testosterone). But there’s also protein hormones. Honestly dunno but I expect we’d understand the effects of those kinds of molecules fairly well, if only because almost for all of them there is a condition where you have too little or too much of it providing a natural experiment.
Hm. TBC, the broader category would be “molecule that would activate master regulation of one or more gene regulatory networks related to brain function”, e.g. a hormone but maybe also some other things.