Fair, though generally I conflated them because if your molecules aren’t small, due to sheer combinatorics the set of the possible candidates becomes exponentially massive. And then the question is “ok but where are we supposed to look, and by which criterion?”.
Perhaps you misread the OP as saying “small molecules” rather than “small set of molecules”.
Fair, though generally I conflated them because if your molecules aren’t small, due to sheer combinatorics the set of the possible candidates becomes exponentially massive. And then the question is “ok but where are we supposed to look, and by which criterion?”.