this is great, they screened and found the invasion factor in the invasive organs that allow Toxo and malaria to slither inside cells and infect.
“Secondary screens identify as an invasion factor the claudin-like apicomplexan microneme protein (CLAMP), which resembles mammalian tight-junction proteins and localizes to secretory organelles, making it critical to the initiation of infection. CLAMP is present throughout sequenced apicomplexan genomes and is essential during the asexual stages of the malaria parasite Plasmodium falciparum. These results provide broad-based functional information on T. gondii genes and will facilitate future approaches to expand the horizon of antiparasitic interventions.”
Virus-Like Nanoparticle Vaccine Confers Protection against Toxoplasma gondii.
Upon challenge infection with a lethal dose of T. gondii (ME49), all vaccinated mice survived, whereas all naïve control mice died. Vaccinated mice showed significantly reduced cyst load and cyst size in the brain.
CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes.
http://www.ncbi.nlm.nih.gov/pubmed/27594426?dopt=Abstract#
this is great, they screened and found the invasion factor in the invasive organs that allow Toxo and malaria to slither inside cells and infect.
“Secondary screens identify as an invasion factor the claudin-like apicomplexan microneme protein (CLAMP), which resembles mammalian tight-junction proteins and localizes to secretory organelles, making it critical to the initiation of infection. CLAMP is present throughout sequenced apicomplexan genomes and is essential during the asexual stages of the malaria parasite Plasmodium falciparum. These results provide broad-based functional information on T. gondii genes and will facilitate future approaches to expand the horizon of antiparasitic interventions.”
Virus-Like Nanoparticle Vaccine Confers Protection against Toxoplasma gondii.
http://www.ncbi.nlm.nih.gov/pubmed/27548677?dopt=Abstract#
Upon challenge infection with a lethal dose of T. gondii (ME49), all vaccinated mice survived, whereas all naïve control mice died. Vaccinated mice showed significantly reduced cyst load and cyst size in the brain.