Aesthetic preferences are a huge part of our personalities, who would agree to any enhancement that would destroy them? And as long as they’re present, a transhuman will be even more effective at making everything look, sound, smell etc. beautiful — in some form or another (maybe in a simulation if it’s detailed enough and if we decide there’s no difference), because a transhuman will be more effective at everything.
If you’re talking about the human body specifically, I don’t think a believable LMD (with artificial skin and everything) is impossible. Or maybe we’ll find a way to build organic bodies with some kind of reciever instead of a brain, to be controlled remotely by an uploaded mind. Or we’ll settle for a simulation, who knows. Smarter versions of us will find a solution.