It looks like it might be supportive, but it also looks crap. No mention of blinding, randomising, or placebo in the abstract.
Can anyone see the actual paper and link to it here? And can anyone work out whether these guys are allies of Wilson, or trying to break him? Because that matters.
Looks solid, and looks like refutation. They claim normal average core temperatures in CFS.
I have quibbles, of course:
I’d expect the core temperature to be well defended. So I’m not worried by that per se, but they do talk about relation to oral temperature, and they do talk about metabolic rate, so they’ve obviously thought about it, and I can’t quite work out what they did there.
Also, the reason that they’re measuring this is because their CFS patients have all been complaining about low oral temperatures and the fact that even when they’ve got a fever, they’re not hot. So errr?? Do all the CFS patients believe this theory and are (un)consciously faking? I mean, I can believe that, but is it true that all CFS patients think this theory is true? Who is telling CFS patients to take their temperatures and why?
On the other hand, their actual graphs do look funny. There’s a strange shape to the CBT vs time graph in CFS, but n=7, I think, so maybe that’s just noise.
Are actually claiming HIGHER peripheral temperatures in Fibromyalgia. But I think they’re measuring during the day. I’ve no idea how to explain that, or what it might mean.
Barnes claimed: Measure axillary temperature on waking. Should be 98.6+/-0.2F (so 37C+/-0.1), lower is bad. Treat with lots of thyroid (1/2-2 grains).
I claim (from just me, and I am perfectly capable of fooling myself): measure oral temperature on waking. Was low (~36.1), has gone higher (36.6-7-8-9) under influence of small amounts of thyroid (1/3 grain). Feel fine now.
Can anyone find: Large numbers of CFS/FMS patients have normal metabolic rate while sleeping or just after waking, no exercise allowed, or normal axillary or oral temperature on waking, again no exercise allowed?
Because that’s what I’m looking for at the moment, and it is refutation. I will have to pull off some clever moves indeed to get round that.
Oh, yes, and there’s a paper by Lowe himself, finding exactly what I expect him to find:
Can anyone dig up quibbles with this that can make me discount it?
Oh Jesus:
Clinical Response to Thyroxine Sodium in Clinically
Hypothyroid but Biochemically Euthyroid Patients
G. R. B. SKINNER MD DSc FRCPath FRCOG, D. HOLMES, A. AHMAD PhD, J.
A. DAVIES BSc and J. BENITEZ MSc
Vaccine Research Trust, 22 Alcester Road, Moseley, Birmingham B13 8BE, UK
This I can’t explain at all! He treated CFS people with tiny amounts of T4, and worked up the dose until they were all better. Worked a treat, apparently. Can anyone break it.
It simultaneously breaks me and proves that CFS is a thyroid problem. I think. Help! Again, no placebos, but a large clinical trial that seems to have worked, by a careful man.
I wouldn’t dream of suggesting that anyone steal this using sci-hub.io by typing the title into the search box and then solving the CAPTCHA even though it’s all in Russian. You should write to the authors and request a copy instead.
ADD EVIDENCE FOR OR AGAINST HERE
Found this for “Wilson’s syndrome”, but can only see the abstract:
http://www.ncbi.nlm.nih.gov/pubmed/16883675
It looks like it might be supportive, but it also looks crap. No mention of blinding, randomising, or placebo in the abstract.
Can anyone see the actual paper and link to it here? And can anyone work out whether these guys are allies of Wilson, or trying to break him? Because that matters.
This, on the other hand:
http://www.ncbi.nlm.nih.gov/pubmed/9513740
Looks solid, and looks like refutation. They claim normal average core temperatures in CFS. I have quibbles, of course:
I’d expect the core temperature to be well defended. So I’m not worried by that per se, but they do talk about relation to oral temperature, and they do talk about metabolic rate, so they’ve obviously thought about it, and I can’t quite work out what they did there.
Also, the reason that they’re measuring this is because their CFS patients have all been complaining about low oral temperatures and the fact that even when they’ve got a fever, they’re not hot. So errr?? Do all the CFS patients believe this theory and are (un)consciously faking? I mean, I can believe that, but is it true that all CFS patients think this theory is true? Who is telling CFS patients to take their temperatures and why?
On the other hand, their actual graphs do look funny. There’s a strange shape to the CBT vs time graph in CFS, but n=7, I think, so maybe that’s just noise.
These guys:
http://www.sciencedirect.com/science/article/pii/S0024320515301223
Are actually claiming HIGHER peripheral temperatures in Fibromyalgia. But I think they’re measuring during the day. I’ve no idea how to explain that, or what it might mean.
Barnes claimed: Measure axillary temperature on waking. Should be 98.6+/-0.2F (so 37C+/-0.1), lower is bad. Treat with lots of thyroid (1/2-2 grains).
I claim (from just me, and I am perfectly capable of fooling myself): measure oral temperature on waking. Was low (~36.1), has gone higher (36.6-7-8-9) under influence of small amounts of thyroid (1/3 grain). Feel fine now.
Can anyone find: Large numbers of CFS/FMS patients have normal metabolic rate while sleeping or just after waking, no exercise allowed, or normal axillary or oral temperature on waking, again no exercise allowed?
Because that’s what I’m looking for at the moment, and it is refutation. I will have to pull off some clever moves indeed to get round that.
Oh, yes, and there’s a paper by Lowe himself, finding exactly what I expect him to find:
http://www.ncbi.nlm.nih.gov/pubmed/16810133
Can anyone dig up quibbles with this that can make me discount it?
Oh Jesus:
Clinical Response to Thyroxine Sodium in Clinically Hypothyroid but Biochemically Euthyroid Patients G. R. B. SKINNER MD DSc FRCPath FRCOG, D. HOLMES, A. AHMAD PhD, J. A. DAVIES BSc and J. BENITEZ MSc Vaccine Research Trust, 22 Alcester Road, Moseley, Birmingham B13 8BE, UK
This I can’t explain at all! He treated CFS people with tiny amounts of T4, and worked up the dose until they were all better. Worked a treat, apparently. Can anyone break it.
It simultaneously breaks me and proves that CFS is a thyroid problem. I think. Help! Again, no placebos, but a large clinical trial that seems to have worked, by a careful man.
I wouldn’t dream of suggesting that anyone steal this using sci-hub.io by typing the title into the search box and then solving the CAPTCHA even though it’s all in Russian. You should write to the authors and request a copy instead.