Hopefully and Michael,
Whatever your current estimates of the probability of success, Eliezer here has a point that seems to have been missed.
His line is:
There are reasons why one would legitimately be depressed.
Unhappy relationship is one.
Frequently those reasons underly claims that life is meaningless.
We would need to assuage most such issues in order to have a legitimate case to consider whether life is meaningless
Some other legitimate depressors:
lack of health
lack of efficacy
and Fear of Death.
Since all of those could lead to a depressive state and the claim that life is meaningless, we would have to address all of those before we could deal with the meaninglessness problem.
If any of y’all have a better present solution for Fear of Death than cryonics (regardless your estimate of its success), there are a lot of folks spending money on cryonics that would love to talk to you.
Also, there may be a misconception re: cryonics and its promises. The claim is that med-tech is advancing, and it is somewhere between not-inconceivable and likely that in the future, technologies such as mental backups, fast-grow tech, rejuvenation treatments and uploading will create an effective impossibility of accidental or age-related death. Hence removing the fear of death for the near (pre- solar death) future.