Why exactly is it better than, say, cutting brain into into pieces and preserving them with formaldehyde? (And/or other cross-linking preservatives). Freezing really shreds everything cryoprotectants do not reach, and possibly dissolves protein oligomers in places cryoprotectants do reach. Either can cause loss of information.
Why exactly is it better than, say, cutting brain into into pieces and preserving them with formaldehyde? (And/or other cross-linking preservatives). Freezing really shreds everything cryoprotectants do not reach, and possibly dissolves protein oligomers in places cryoprotectants do reach. Either can cause loss of information.