How does Original Antigenic Sin work for natural immunity vs vaccine derived immunity? Is it a stronger impediment for one vs the other?
Also, this whole topic seems (I think) to be mostly independent of the T-cell immunity that gives you the baseline immunity to severe disease—the reason for Zvi’s low estimate of full immune escape, I think.
This doesn’t directly answer your question but it appears that people who received mRNA vaccines produced fewer antibodies for one of the four endemic coronaviruses than those who were naturally infected. If that’s true, it’s very encouraging news as far as adapting vaccines is concerned:
How does Original Antigenic Sin work for natural immunity vs vaccine derived immunity? Is it a stronger impediment for one vs the other?
Also, this whole topic seems (I think) to be mostly independent of the T-cell immunity that gives you the baseline immunity to severe disease—the reason for Zvi’s low estimate of full immune escape, I think.
This doesn’t directly answer your question but it appears that people who received mRNA vaccines produced fewer antibodies for one of the four endemic coronaviruses than those who were naturally infected. If that’s true, it’s very encouraging news as far as adapting vaccines is concerned:
https://www.medrxiv.org/content/10.1101/2021.09.30.21264363v1