40+ years ago when people were investigating the mechanism of action of clozapine, they knew that some of its benefits might have had to do with muscarinic receptors as well. In fact, some of these investigations were done at Pfizer!
https://paperpile.com/shared/shUc~GTZ0T3qFvQ84LykSmA
So the story that cobenfy has a brand new mechanism of action isn’t quite right, but it is the first approved drug to have deliberately targeted muscarinic receptors.
Clozapine has been a highly underutilized drug for decades https://psychiatryonline.org/doi/full/10.1176/appi.ps.201700162
40+ years ago when people were investigating the mechanism of action of clozapine, they knew that some of its benefits might have had to do with muscarinic receptors as well. In fact, some of these investigations were done at Pfizer! https://paperpile.com/shared/shUc~GTZ0T3qFvQ84LykSmA
So the story that cobenfy has a brand new mechanism of action isn’t quite right, but it is the first approved drug to have deliberately targeted muscarinic receptors.