One of the strongest cases for placebo effect is IV morphine, whose powerful painkilling effects can in many cases be simulated by IV saline which someone says is morphine. Finding the placebo effect with a professionally-administered IV drug usually given in hospital suggests it’s not just an issue of compliance.
The famous story here is that of Henry Beecher, usually considered discoverer of the placebo. From the Telegraph:
The power of the placebo first came to light during the Second World War. Morphine was in short supply in military field hospitals and an American anaesthetist called Henry Beecher, who was preparing to treat a soldier with terrible injuries, feared that without the drug the operation could induce a fatal heart attack. In desperation, one of the nurses injected the man with a harmless solution of saline. To Beecher’s surprise the patient settled down as if he had been given morphine and felt little pain during the operation.
This abstract frustrates me. How effective was the placebo compared to the iv morphine? Are they saying that it’s as effective till 4-6mg of IV morphine? Any other studies with complementary or contrasting evidence? Thanks for the share by the way.
One of the strongest cases for placebo effect is IV morphine, whose powerful painkilling effects can in many cases be simulated by IV saline which someone says is morphine. Finding the placebo effect with a professionally-administered IV drug usually given in hospital suggests it’s not just an issue of compliance.
Would appreciate some citations...
The famous story here is that of Henry Beecher, usually considered discoverer of the placebo. From the Telegraph:
Or for a more formal study, see Analgesic responses to morphine and placebo in individuals with postoperative pain
This abstract frustrates me. How effective was the placebo compared to the iv morphine? Are they saying that it’s as effective till 4-6mg of IV morphine? Any other studies with complementary or contrasting evidence? Thanks for the share by the way.