Will some genetically engineered humans have misaligned goals? The answer here is almost certainly yes.
If by “misaligned” all we mean is that some of them have goals that are not identical to the goals of the rest of humanity, then the answer is obviously yes. Individuals routinely have indexical goals (such as money for themselves, status for themselves, taking care of family) that are not what the rest of humanity wants.
If by “misaligned” what we mean is that some of them are “evil” i.e., they want to cause destruction or suffering on purpose, and not merely as a means to an end, then the answer here is presumably also yes, although it’s less certain.
This is very strange reasoning. Misaligned goals mean that entity basically doesn’t care about our existence or well-being, it doesn’t gain anything from us being alive and well relatively to us turning into paperclips. For genetically engineered humans reversal is very likely to be true: they are going to love other humans, be friends with them or take pride from position in human social hierarchy, even if they are selfish by human standards, and it is not clear why they should be selfish.
This is very strange reasoning. Misaligned goals mean that entity basically doesn’t care about our existence or well-being, it doesn’t gain anything from us being alive and well relatively to us turning into paperclips. For genetically engineered humans reversal is very likely to be true: they are going to love other humans, be friends with them or take pride from position in human social hierarchy, even if they are selfish by human standards, and it is not clear why they should be selfish.