I assume that many will agree with your response for the mind “uploading” scenario. At the same time I think we can safely say that there would be at least some people that would go through with it. Would you consider those minds that are “uploaded” as persons or would you object to that?
Besides that “uploading” scenario, what would your limit be for other plausible transhumanist modifications?
Humans still don’t seem to care much about the minimization of harm among all their foolish goals. Why not crush such selfish animals? Conscious beings that fail to criticize their own evolved “alignment” aren’t worth preserving, extinction would be a mercy.