Well the proposed Tay-Sachs benefit is an example of a trade-off that probably isn’t present in our genome to as large an extent as was supposed during the hey day of the overdominance hypothesis. For heterozygote advantages to be a serious ethical issue would require the advantages they conferred to be difficult to obtain by other means, IQ I can see, but anyone rich enough to afford a designer baby probably isn’t going to bother giving it a sickle cell allele.
Well the proposed Tay-Sachs benefit is an example of a trade-off that probably isn’t present in our genome to as large an extent as was supposed during the hey day of the overdominance hypothesis. For heterozygote advantages to be a serious ethical issue would require the advantages they conferred to be difficult to obtain by other means, IQ I can see, but anyone rich enough to afford a designer baby probably isn’t going to bother giving it a sickle cell allele.