Congrats on the new company! I think this is potentially quite an important effort, so I hope anyone browing this forum who has a way to get access to biobank data from various sources will reach out.
One of my greatest hopes for these new models is that they will provide a way for us to predict the effects of novel genetic variants on traits like intelligence or disease risk.
When I wrote my post on adult intelligence enhancement at the end of 2023, one of the biggest issues was just how many edits we would need to make to achieve significant change in intelligence.
Neither delivery nor editing tech is good enough yet to make anywhere close to the number of edits needed for adult cognitive enhancement. But it’s plausible that there exist a set of gene edits such that just 10 or 20 changes would have a significant impact.
One of my greatest hopes is that these foundation models will generalize well enough out-of-distribution that we can make reasonably accurate predictions about the effect of NEW genetic variants on traits like intelligence of health. If we can, (and ESPECIALLY if we can also predict tolerance to these edits), it could 10x the impact of gene editing.
This may end up being one of the most important technologies for adult cognitive enhancement. So I hope anyone who might be able to help with data access reaches out to you!
Congrats on the new company! I think this is potentially quite an important effort, so I hope anyone browing this forum who has a way to get access to biobank data from various sources will reach out.
One of my greatest hopes for these new models is that they will provide a way for us to predict the effects of novel genetic variants on traits like intelligence or disease risk.
When I wrote my post on adult intelligence enhancement at the end of 2023, one of the biggest issues was just how many edits we would need to make to achieve significant change in intelligence.
Neither delivery nor editing tech is good enough yet to make anywhere close to the number of edits needed for adult cognitive enhancement. But it’s plausible that there exist a set of gene edits such that just 10 or 20 changes would have a significant impact.
One of my greatest hopes is that these foundation models will generalize well enough out-of-distribution that we can make reasonably accurate predictions about the effect of NEW genetic variants on traits like intelligence of health. If we can, (and ESPECIALLY if we can also predict tolerance to these edits), it could 10x the impact of gene editing.
This may end up being one of the most important technologies for adult cognitive enhancement. So I hope anyone who might be able to help with data access reaches out to you!