A few days ago I was listening to the Bloomberg Odd Lots podcast episode on Chinese Peptides, and the first guest mentioned reading articles on LessWrong about retatrutide, and the second guest owns the company I buy peptides for my own research from. This felt like a sign that I should finally write a final update to 30 Days of Retatrutide.
This will be brief since I don’t think there’s actually much to talk about.
I stopped trying to lose weight since I hit my target BMI, my weight-related medical issues resolved themselves, and I’m more focused on strength now.
I need around 1/4th of the dose I was taking to remain weight stable at my target weight.
Diluting the drug better, only taking it once a week, and taking it in the morning seems to help with swelling.
I still don’t think there’s any direct effect on willpower, although not being distracted by snacks is useful.
Weight
The point where I started retatrutide is very obvious. There was a ~2 week delay between dropping the dose and weight going back up.
Around November 1st, I was at a reasonable BMI (22) and decided to start focusing on strength instead of weight loss. Stopping retatrutide entirely brought my appetite back too strongly, so I started taking quarter doses a week later. I also started working out more and taking creatine, so the 8 lb gain here is largely expected between creatine and glycogen.
I’m also not particularly worried about small amounts of weight gain as I work on muscle, since it’s trivial to lose it again if I want to.
Side-effects
I noted getting injection site redness and swelling in the last article. Changing to a smaller needle doesn’t seem to help, although using a replaceable needing and switching it between extracting the drug and injecting it helped with consistency (every once in a while, the needle would be obviously blunt and hard to inject).
Diluting it slightly less (and later using less as I dropped the dose) seems to have helped, and more recently, doing the injection earlier in the day (vs. at night) seems to have also helped. I also only take it once a week now.
I’m not entirely sure what I changed, but I only get minor redness now.
I no longer get any skin sensitivity or heartburn. My resting heart rate and HRV are still elevated even at a lower dose, but this doesn’t seem to get in the way of exercise so I’m not worried about it.
Update: 5 months of Retatrutide
A few days ago I was listening to the Bloomberg Odd Lots podcast episode on Chinese Peptides, and the first guest mentioned reading articles on LessWrong about retatrutide, and the second guest owns the company I buy peptides for my own research from. This felt like a sign that I should finally write a final update to 30 Days of Retatrutide.
This will be brief since I don’t think there’s actually much to talk about.
I stopped trying to lose weight since I hit my target BMI, my weight-related medical issues resolved themselves, and I’m more focused on strength now.
I need around 1/4th of the dose I was taking to remain weight stable at my target weight.
Diluting the drug better, only taking it once a week, and taking it in the morning seems to help with swelling.
I still don’t think there’s any direct effect on willpower, although not being distracted by snacks is useful.
Weight
Around November 1st, I was at a reasonable BMI (22) and decided to start focusing on strength instead of weight loss. Stopping retatrutide entirely brought my appetite back too strongly, so I started taking quarter doses a week later. I also started working out more and taking creatine, so the 8 lb gain here is largely expected between creatine and glycogen.
I’m also not particularly worried about small amounts of weight gain as I work on muscle, since it’s trivial to lose it again if I want to.
Side-effects
I noted getting injection site redness and swelling in the last article. Changing to a smaller needle doesn’t seem to help, although using a replaceable needing and switching it between extracting the drug and injecting it helped with consistency (every once in a while, the needle would be obviously blunt and hard to inject).
Diluting it slightly less (and later using less as I dropped the dose) seems to have helped, and more recently, doing the injection earlier in the day (vs. at night) seems to have also helped. I also only take it once a week now.
I’m not entirely sure what I changed, but I only get minor redness now.
I no longer get any skin sensitivity or heartburn. My resting heart rate and HRV are still elevated even at a lower dose, but this doesn’t seem to get in the way of exercise so I’m not worried about it.