For macroscopic rotation:
Blood vessels cannot rotate continuously, so nutrients cannot be provided to the rotating element to grow it.
Without smooth surfaces to roll on, rolling is not better than walking.
There are other uses for macroscopic rotation besides rolling on wheels, e.g. propellers, gears, flywheels, drills, and turbines. Also, how to provide nutrients to detached components, or build smooth surfaces to roll on so your wheels will be useful, seem like problems that intelligence is better at solving than evolution.
May I ask which medications?