I don’t fully understand your implicatioks of why unpredictable things should not be frightening. In general, there is a difference between understanding and creating.
The weather is unpredictable but we did not create it; where we did and do create it, we indeed seem to be too careless. For human brains, we at least know that preferences are mostly not too crazy, and if they are, capabilities are not superhuman. With respect to the immune system, understanding may be not very deep, but intervention is mostly limited by understanding, and where that is not true, we may be in trouble.
I don’t fully understand your implicatioks of why unpredictable things should not be frightening. In general, there is a difference between understanding and creating. The weather is unpredictable but we did not create it; where we did and do create it, we indeed seem to be too careless. For human brains, we at least know that preferences are mostly not too crazy, and if they are, capabilities are not superhuman. With respect to the immune system, understanding may be not very deep, but intervention is mostly limited by understanding, and where that is not true, we may be in trouble.