There are two Indian vaccines close to finishing their trials in India. On that note, Pfizer was denied approval in India since it did not use Indian subjects in their trials. There is a Chinese vaccine. There are one or two more versions of Russian vaccines still going through trials hopefully crossing every t because Russia does want to play by the rules and sell in EU at least. it just wanted to protect their population more.
cistran
How many times do you snort adjuvants with your food? I bet the concentration of adjuvants in your homebrew is much higher than what a person could accidentally inhale. This is on purpose of course, so that you are much more likely to get an immune response. But your comparison with things that are not designed to elicit an immune response seems somewhat optimistic.
For children, it is as far as we know.
That’s is an easy calculation. Life value can change later and there might be a more attractive bet you will be forgoing by taking this one, say 10 million for 50% chance of dying.
You are not allowed to not care for yourself. Particularly, you should take care that you are not infected, because if you are not infected you cannot spread the virus.
That’s the point of the post. Given a large number of contacts, P(infecting at least one of them) > P(you are infected)
Lets illustrate. Suppose P1(you are infected AND (you are asymptomatic OR you are pre-symptomatic))
P2(infecting any one of your contacts) = P2′*P1 = where P2′ is the probability of infection per contact
Then P3(infecting at least one of your contacts out of N) = 1- (1-P2)^N provided none of the N contacts are themselves infected.
And in P3>P1 it is always possible to solve for N.
or, you could use unhealthy only to mean things which are likely to decrease your health (mental health included)
Trying to help them how? Education? Financial incentives to vaccinate? Social disincentives to hold out?
At least some forms of trying will not be cost-effective.
Is the JHU tracking site at https://coronavirus.jhu.edu/data very inferior to covid tracking project?
Does accessing antibody test results break the double blind? Are you sure you didn’t consent to not doing that?
You are way better than average at avoiding infection then. CDC estimated that from February to December that there were a total of 83.1 million infections in US, over 20% of population.
PR is something that can be done to you as in negative PR. There is no negative reputation, or negative honor, there is only slander.
And yet, Piratebay stays online.
Your machine will make you permanently stupider than you could be in a real world since it would continue forcing reasoning errors on you. Once you realize that, how can you trust that machine experience will remain better in pain/pleasure balance. In other words, what makes you confident the machine won’t extract a payment of pain out of you in exchange for all the bliss you received?
But dishonor is rarely used in its transitive meaning. It is difficult to reduce someone’s honor by dishonoring somebody, only your own honor can be dishonored by you.
All your examples point to self-inflicted reputation loss. I am talking about reputation loss inflicted from outside.
Here is my counter-example: Doctor Ignaz Semmelweis, the inventor of hand hygiene in medical (specifically OBGYN) practice. He was reviled and ridiculed and driven insane by the medical establishment of Vienne.
A very important special case of this: There is no evidence that COVID vaccination reduces transmission.
Any proposal that brings us closer to hundred million dollars nuke will probably be bad for preventing nuclear incident of the mushroom cloud kind. I think your proposal of reducing the size and yield of nuclear weapons also reduces its cost.
A country like North Korea is unlikely to strike first with nuclear weapons precisely for reasons you mentioned. But possession of them is a significant deterrent against invasion by a conventional military force or insurrection aided by an outside military force, such as ones happened in Iraq and Libya. Any government concerned by a threat of such invasion or insurrection would love to emulate North Korean example now that it is clear that any other safety guarantees are insufficient. Any major actor that actively pursues the strategy of making its nuclear weapons smaller and cheaper must take care that they are not so small and cheap, that any government with a hundred million dollar budget can afford one.
Saving lives now may be worth more than saving lives later.
This is a conversation with an MD I recorded which may answer some of the reluctance:
tldr; An untested delivery mode scares an MD to think that neurodegenerative diseases will increase in vaccinated.
I think lipid nanoparticles may have too broad a tropism, far broader even than attenuated virus vaccines (which are still limited to the tropism of the wild-type virus), and thus could pose a uniquely high safety hazard due to cytotoxic attack on the broad cellular range that uptakes the LNPs. Since the LNPs would enter cells via endocytosis, the SARS-CoV-2 epitopes would be expressed on MHC-1 molecules, making them targets of cytotoxic CD8 lymphocytes, attacking a much greater range of cells than any previous vaccine modality. This is concerning in general, but it’s a nightmare scenario if the vaccines are crossing the blood-brain barrier and endocytosing into e.g. oligodendrocytes (multiple sclerosis risk) or motor neurons (which could possibly cause an ALS-type picture). No other vaccine has this broad tropism. That is THE major safety concern here.
1. Because of the anatomy and circulatory trajectory from the deltoid and cephalic vein (essentially a straight shot into the SVC), if enough “spillover LNPs” are getting shuttled into the right atrium and transiting through the pulmonary circulation — which could be high, another reference here for the rich vasculature around IM injection — then one of their earliest stops on the map after exiting the heart would be in tissues serviced by branches of the common carotid and subclavian arteries (including the CNS), enhancing delivery to tissues behind the blood-brain barrier simply due to higher relative concentration at tissue corridors more proximal to the injection site.
2. Even if initial transit through the BBB and into other sensitive tissue parenchyma is relatively low, there’d be a cumulative effect with each booster delivering more spillover LNPs to those non-local sites.
3. Related to that point, the duration of immunity is still unclear, and there seems to be general agreement that while COVID-19 symptoms are reduced with the immunization, viral spread is not. If antibody and memory B/T-cell levels wane within a few months after vaccination, then we’d be looking at repeated boosters possibly multiple times a year given ongoing community dissemination. And since the development of many e.g. CNS disorders is gradual — with subclinical issues taking shape over years before clinical manifestations become apparent (as seen in MS and ALS) — such cumulative damage likely wouldn’t raise red flags at first, but could increase in likelihood with successive boosters.