Selective activation of the mu opioid receptors by a full mu opioid receptor agonist is the closest recipe we have for pure bliss without desire. But this activation needs to be in the ultimate hedonic hotspots of nucleus accumbens and posterior ventral pallidum. What is the gene expression profile of these cells? Why are they so special?
David Pearce commented on this post on Facebook:
and more importantly, how do I wirehead using them instead of the aforementioned wanting cells.