More on lipid oxidation: it also depends on the composition (polyunsaturated to saturated fat ratio) of the lipids that compose the cell’s walls. You also need to account for all the other highly reactive cell oxidation byproducts (eg 9-HNE, michael adducts, methylglyoxal, CML) as well as the overall redox potential of the cell (eg glutathionine seems to be an abundant antioxidant that reacts with many highly reactive byproducts..)
Additionally in the case of arteriosclerosis, it also depends on the ratio/supply of oxidized cholesterol (particularly keto-cholesterol). What you described for arteriosclerosis seems generalized for any cell, but it’s clear that there’s something happening on the artery walls at a faster rate that than what’s happening to other cells/tissues and you haven’t fully accounted for the difference yet.
Fenton chemistry has feedback loops with ascorbic acid (higher levels of metals can turn ascorbic acid into a pro-oxidant).
More on lipid oxidation: it also depends on the composition (polyunsaturated to saturated fat ratio) of the lipids that compose the cell’s walls. You also need to account for all the other highly reactive cell oxidation byproducts (eg 9-HNE, michael adducts, methylglyoxal, CML) as well as the overall redox potential of the cell (eg glutathionine seems to be an abundant antioxidant that reacts with many highly reactive byproducts..)
Additionally in the case of arteriosclerosis, it also depends on the ratio/supply of oxidized cholesterol (particularly keto-cholesterol). What you described for arteriosclerosis seems generalized for any cell, but it’s clear that there’s something happening on the artery walls at a faster rate that than what’s happening to other cells/tissues and you haven’t fully accounted for the difference yet.
Fenton chemistry has feedback loops with ascorbic acid (higher levels of metals can turn ascorbic acid into a pro-oxidant).
[quantification of AGEs—https://www.fightaging.org/archives/2020/11/towards-better-quantification-of-ages-and-cross-links-in-human-tissues/ ]