https://www.science.org/doi/abs/10.1126/science.1174443 seems to be the first paper. It does have a small sample size and thus is only able to produce candidates, but it results in the later paper not randomly searching over all possible gene mutations.
My main point is that there are papers that made independent observations and thus arguments that a single paper doesn’t demonstrate the effect doesn’t hold. I didn’t copy the exact minute numbers that the EA cause report had because I was unsure about the exactness of the data.
In the case of orexin, my argument doesn’t just rest on the DEC2 gene.
The experiments that improved performance in sleep-deprived rhesus monkeys happened before the discovery of the link between the DEC2 mutation and orexin.
The observations in Astyanax mexicanus seem independent from my perspective. Attempts to make Astyanax mexicanus a model organism aren’t driven by sleep researchers but because it’s interesting for studying evolution.
Orexin deficiency causing Narcolepsy type 1 is independent of any findings about the DEC2 gene as well.
As far as the linked post of Scott goes, it says nothing about experiments on animals other than humans. Gene knockout studies in mice and Drosophila seem to me like a pretty good way to measure the influence of a gene.
https://www.science.org/doi/abs/10.1126/science.1174443 seems to be the first paper. It does have a small sample size and thus is only able to produce candidates, but it results in the later paper not randomly searching over all possible gene mutations.
My main point is that there are papers that made independent observations and thus arguments that a single paper doesn’t demonstrate the effect doesn’t hold. I didn’t copy the exact minute numbers that the EA cause report had because I was unsure about the exactness of the data.
I’m not sure if you have read the story of 5HTTLPR and all the independent studies which found it to have an effect, but if you haven’t you should.
In the case of orexin, my argument doesn’t just rest on the DEC2 gene.
The experiments that improved performance in sleep-deprived rhesus monkeys happened before the discovery of the link between the DEC2 mutation and orexin.
The observations in Astyanax mexicanus seem independent from my perspective. Attempts to make Astyanax mexicanus a model organism aren’t driven by sleep researchers but because it’s interesting for studying evolution.
Orexin deficiency causing Narcolepsy type 1 is independent of any findings about the DEC2 gene as well.
As far as the linked post of Scott goes, it says nothing about experiments on animals other than humans. Gene knockout studies in mice and Drosophila seem to me like a pretty good way to measure the influence of a gene.