10mg pregnenolone: sometimes a bit more, aiming for blood levels around 60-80 ng/dL. Seems to increase my mental energy.
25mg dhea: I’m uncertain about the dose, and I’m experimenting a bit to see if I can detect effects.
~3000 IU vitamin D: aiming for blood levels just over 50 ng/mL.
100mcg vitamin K2 mk7
1mg folate: I’m homozygous for MTHFR C677T; it seems to improve my mood.
1mg B12: it’s keeping my blood levels around 800 pg/mL, compared to < 500 before supplementing.
1g omega-3 (currently in the form of Bulletproof Omega Krill Complex).
Stem Cell 100, once per day
500mg N-Acetyl-L-Cysteine: possibly helps lower my homocysteine, but my results are pretty noisy.
ashwagandha: I had very interesting thyroid effects when I was getting too much iodine from kelp, but now that I’ve fixed my iodine levels, I don’t detect any effects.
curcumin (Life Extension Bio-curcumin): I suspect I have inflammation due to a temporary problem, and will likely go back to taking this less regularly in a few months.
caffeine: from tea, green tea extract pills, or occasionally a 100mg pill.
Supplements taken less than once per day:
creatine, 1 or 2 grams (no clear effects).
melatonin, typically 300mcg, timed release version.
liver, and organ meat pills, from Ancestral Supplements.
green mussel
kratom: typically 0.25 teaspoon of Maeng Da, mildly stimulating with reduced anxiety?
phenibut: taken about once a month, for the anti-anxiety effect, with a bit of stimulation.
A majority of these choices are influenced by Bredesen’s book The End of Alzheimers, or by a prior source with similar advice.
Daily supplements:
10mg pregnenolone: sometimes a bit more, aiming for blood levels around 60-80 ng/dL. Seems to increase my mental energy.
25mg dhea: I’m uncertain about the dose, and I’m experimenting a bit to see if I can detect effects.
~3000 IU vitamin D: aiming for blood levels just over 50 ng/mL.
100mcg vitamin K2 mk7
1mg folate: I’m homozygous for MTHFR C677T; it seems to improve my mood.
1mg B12: it’s keeping my blood levels around 800 pg/mL, compared to < 500 before supplementing.
1g omega-3 (currently in the form of Bulletproof Omega Krill Complex).
Stem Cell 100, once per day
500mg N-Acetyl-L-Cysteine: possibly helps lower my homocysteine, but my results are pretty noisy.
ashwagandha: I had very interesting thyroid effects when I was getting too much iodine from kelp, but now that I’ve fixed my iodine levels, I don’t detect any effects.
ResveraCel (Thorne), contains Nicotinamide Riboside, Quercetin Phytosome, Trans-Resveratrol, Trimethylglycine.
curcumin (Life Extension Bio-curcumin): I suspect I have inflammation due to a temporary problem, and will likely go back to taking this less regularly in a few months.
caffeine: from tea, green tea extract pills, or occasionally a 100mg pill.
Supplements taken less than once per day:
creatine, 1 or 2 grams (no clear effects).
melatonin, typically 300mcg, timed release version.
liver, and organ meat pills, from Ancestral Supplements.
green mussel
kratom: typically 0.25 teaspoon of Maeng Da, mildly stimulating with reduced anxiety?
phenibut: taken about once a month, for the anti-anxiety effect, with a bit of stimulation.
A majority of these choices are influenced by Bredesen’s book The End of Alzheimers, or by a prior source with similar advice.
Oh interesting. Do you know if anyone’s done an epistemic spot-check of The End of Alzheimers?
I wrote a long review with some comments on the extent to which I trust the book.