From what I understand the pipeline depends strongly on homology to existing proteins that have determined structures to use substitution correlations to create an interaction graph which it then allows to evolve via learned rules.
I strongly suspect that as such it will not be very good at orphans without significant homology, be it sequence to structure or the reverse.
From what I understand the pipeline depends strongly on homology to existing proteins that have determined structures to use substitution correlations to create an interaction graph which it then allows to evolve via learned rules.
I strongly suspect that as such it will not be very good at orphans without significant homology, be it sequence to structure or the reverse.