“Aside from the test result, we do have one more small piece of information to update on: I was quite congested for 1-2 days after the most recent three doses (and I was generally not congested the rest of the week). That’s exactly what we’d expect to see if the vaccine is working as intended, and it’s pretty strong evidence that it’s doing something.”
Agree that this is evidence it is doing something, but my strong prior is that the adjuvant alone (chitosan) would cause this to happen.
I’m also unclear about why you chose the weekly schedule, or if you waited long enough to see any impact. (Not that the RadVac test would tell you anything.) The white paper suggests *at least* one week between doses, and suggests taking 3 doses, for healthy young adults.
According to the white paper, you’re likely to be protected, and I think continuing now would add danger without corresponding benefit. You said in the original post that you might continue dosing. I don’t know enough to comment usefully about either immune tolerance or adjuvant hyperstimulation, but I suggest talking to a immunologist about those risks and how they change if you in fact continue and try “more dakka,” since continuing to does seems like it would increase those risks.
Strongly agree that ELISA tests are more valuable than more RadVac, and it would be at least moderate evidence one way or another. (But even if you can induce immune reactions to parts of the virus, it’ unclear how much that would actually reduce your risk if infected.)
My current plan is to do one more dose, to make sure we’ve had three total doses with all nine peptides, then cut it off there. In general, I expect more dakka to be valuable mainly if the dosage is sufficient to induce response in some people but not everyone, so e.g. if we saw a response in my girlfriend but not in me then I’d be a lot more inclined to add another couple doses.
Agree that this is evidence it is doing something, but my strong prior is that the adjuvant alone (chitosan) would cause this to happen.
I’m also unclear about why you chose the weekly schedule, or if you waited long enough to see any impact. (Not that the RadVac test would tell you anything.) The white paper suggests *at least* one week between doses, and suggests taking 3 doses, for healthy young adults.
According to the white paper, you’re likely to be protected, and I think continuing now would add danger without corresponding benefit. You said in the original post that you might continue dosing. I don’t know enough to comment usefully about either immune tolerance or adjuvant hyperstimulation, but I suggest talking to a immunologist about those risks and how they change if you in fact continue and try “more dakka,” since continuing to does seems like it would increase those risks.
Strongly agree that ELISA tests are more valuable than more RadVac, and it would be at least moderate evidence one way or another. (But even if you can induce immune reactions to parts of the virus, it’ unclear how much that would actually reduce your risk if infected.)
My current plan is to do one more dose, to make sure we’ve had three total doses with all nine peptides, then cut it off there. In general, I expect more dakka to be valuable mainly if the dosage is sufficient to induce response in some people but not everyone, so e.g. if we saw a response in my girlfriend but not in me then I’d be a lot more inclined to add another couple doses.