Re: Why not do 300k instead of 30k for vaccine trials? Clearly bigger trials would be better—especially as the current trials aren’t that representative of the general population or the most at-risk groups. But presumably the logistical cost of 10x more patients is significant. You have to be testing all these people for COVID and following up on any possible adverse reactions. I think lack the lack of challenge trials is the biggest problem. (Note that AFAICT, UK trial is likely to happen but not 100% confirmed and it only starts in January.)
Re: Why not do 300k instead of 30k for vaccine trials? Clearly bigger trials would be better—especially as the current trials aren’t that representative of the general population or the most at-risk groups. But presumably the logistical cost of 10x more patients is significant. You have to be testing all these people for COVID and following up on any possible adverse reactions. I think lack the lack of challenge trials is the biggest problem. (Note that AFAICT, UK trial is likely to happen but not 100% confirmed and it only starts in January.)