This is such an incredibly well researched and well thought out post, it’s a surprise and a disappointment that there has been no comments even four years later (I had been looking forward to reading the discussion section). I really have to thank you for the effort you put into compiling the data. It had helped me decide what to try first.
Also, all the top 5 rated antidepressants significantly affect either the dopaminergic system or the norepinephrine system or both, while most antidepressants primarily affect the serotonin system. The treatment of atypical depression is known to improve with the supplementation of psychostimulants like modafinil, buproprion and occasionally ritalin to typical antidepressant therapy. These drugs increases the amount of dopamine and norepinephrine (only dopamine in the case of modafinil) in the synapses. So that could just be the shared thread for why certain antidepressants are more effective than others—by not just increasing serotonin.
By the way could you reupload the excel file? I cannot seem to download it but would really like to look through the data in more detail.
This is such an incredibly well researched and well thought out post, it’s a surprise and a disappointment that there has been no comments even four years later (I had been looking forward to reading the discussion section). I really have to thank you for the effort you put into compiling the data. It had helped me decide what to try first.
Also, all the top 5 rated antidepressants significantly affect either the dopaminergic system or the norepinephrine system or both, while most antidepressants primarily affect the serotonin system. The treatment of atypical depression is known to improve with the supplementation of psychostimulants like modafinil, buproprion and occasionally ritalin to typical antidepressant therapy. These drugs increases the amount of dopamine and norepinephrine (only dopamine in the case of modafinil) in the synapses. So that could just be the shared thread for why certain antidepressants are more effective than others—by not just increasing serotonin.
By the way could you reupload the excel file? I cannot seem to download it but would really like to look through the data in more detail.
(This post was originally posted here, where it got over 250 comments: https://slatestarcodex.com/2015/04/30/prescriptions-paradoxes-and-perversities/)
You can find discussion of this post on Scott’s Blog.